Targeted Protein Degradation Market Size, Share, Competitive Landscape and Forecast Trend Analysis – By Technology (PROTAC, Molecular Glues, LYTACs and Others), By Application (Drug Discovery and Therapy Development), By End-use (Pharmaceutical & Biotechnology Companies, Academic & Research Institutes, Hospital & Clinical Laboratories and Others) & Region – Global Forecasts 2025 - 2035.
- PUBLISHED ON
- 2025-01-09
- NO OF PAGES
- 320
- CATEGORY
- Healthcare & Life Sciences
Market Overview
The Targeted Protein Degradation market growth is predicted to develop at a compound annual growth rate (CAGR) of 21.2% from 2025 to 2035, when global Targeted Protein Degradation market forecast revenue is projected to reach USD 3,468.42 Million in 2035, based on an average growth pattern. The global Targeted Protein Degradation Market Size is estimated to reach a value of USD 546.63 Million in 2025.
SOURCE: We Market Research
The Global Targeted Protein
Degradation (TPD) Market industry analysis refers to the industry focused on
the development and commercialization of therapeutic approaches that
selectively degrade disease-causing proteins using the body’s natural protein
disposal mechanisms. Unlike traditional small-molecule inhibitors, TPD leverages
proteolysis-targeting chimeras (PROTACs), molecular glues, lysosome-targeting
chimaeras (LYTACs), and other novel modalities to eliminate rather than inhibit
specific proteins. The targeted protein degradation
market forecast is poised for substantial growth, driven by technological
innovations, increasing prevalence of chronic diseases, and strategic industry
collaborations. Partnerships between biotechnology firms and pharmaceutical
companies are accelerating the development and commercialization of TPD
therapies.
Global Targeted Protein Degradation Market Scope
|
Report Attributes |
Description |
|
Market Size in 2025 |
USD 546.63 Million |
|
Market
Forecast in 2035 |
USD 3,468.42 Million |
|
CAGR % 2025-2035 |
21.2% |
|
Base
Year |
2024 |
|
Historic Data |
2021-2024 |
|
Forecast
Period |
2025-2035 |
|
Report USP
|
Production, Consumption,
company share, company heatmap, company production capacity, growth factors
and more |
|
Segments
Covered |
By
Technology, By Application, By End-use
and By Region |
|
Regional Scope |
North America,
Europe, APAC, Latin America and Middle East and Africa |
|
Country
Scope |
U.S.; Canada;
U.K.; Germany; France; Italy; Spain; Benelux; Nordic Countries; Russia;
China; India; Japan; South Korea; Australia; Indonesia; Thailand; Mexico;
Brazil; Argentina; Saudi Arabia; UAE; Egypt; South Africa; Nigeria |
Market Dynamics & Restraints
Global Targeted Protein Degradation Market Opportunity:
We Market
Research: Dashboard
Our marketing
platform offers a comprehensive dashboard that provides clients with valuable
insights into global Targeted Protein Degradation market trends over the years.
Included below is a sample image of our dashboard, and specific PDF logins will
be furnished to grant access to this insightful tool.
Targeted Protein Degradation Market Segmentation
The Global Targeted
Protein Degradation Market industry analysis is segmented into by Technology, by
Application, by End-use and by Region. By Technology the market is segmented
into PROTAC, Molecular Glues, LYTACs and Others. On the basis of Application, Targeted
Protein Degradation Market is bifurcated into Drug Discovery and Therapy
Development. In terms of End-use, Targeted Protein Degradation Market is
bifurcated into Pharmaceutical & Biotechnology Companies, Academic &
Research Institutes, Hospital & Clinical Laboratories and Others.
Market- By Technology Analysis
By Technology, the Targeted Protein Degradation market revenue is categories into PROTAC, Molecular Glues, LYTACs and Others. PROTAC segments holds the largest segment in the global Targeted Protein Degradation market share, accounting for approximately 27%. PROTACs accounted for the largest revenue share in the TPD market. This dominance is attributed to their widespread adoption in oncology therapies and proven efficacy in degrading previously undruggable proteins. For instance, in April 2024, Novartis acquired VVD-101, a protein degrader targeting the androgen receptor for prostate cancer, from Vividion Therapeutics, indicating significant investment in PROTAC-based therapies.
The following segments are part of an in-depth
analysis of the global Targeted Protein Degradation market:
|
Market Segments |
|
|
By Technology |
·
PROTAC ·
Molecular Glues ·
LYTACs ·
Others |
|
By
Application |
·
Drug Discovery ·
Therapy Development o
Cancer o
Neurology o
Infectious Diseases o
Cardiovascular Diseases o
Others |
|
By
End-use |
·
Pharmaceutical & Biotechnology Companies ·
Academic & Research Institutes ·
Hospital & Clinical Laboratories ·
Others |
Targeted Protein Degradation Industry: Regional Analysis
North America Market Forecast
North America holds the largest share of the global Targeted Protein Degradation market revenue, accounting for approximately 44% of the market. North America, particularly the United States, is home to some of the world's largest pharmaceutical companies and biotech firms, which significantly invest in the development of targeted protein degradation therapies. The FDA has provided a supportive framework for innovative therapeutics like PROTACs and molecular glues, enabling faster approval times for promising drugs.
Europe Market Statistics
Europe is the
second-largest market for Targeted Protein Degradation industry report. Europe
has numerous leading academic institutions and biotech companies that are
advancing TPD technology. Regulatory bodies such as the European Medicines
Agency (EMA) are actively working to establish regulatory guidelines for
protein degraders. Increased collaboration between biotech firms and academic
institutions is driving early-stage development and clinical trials, especially
for oncology and neurodegenerative disease therapies.
Asia Pacific Market Forecasts
The Asia Pacific
region is projected to experience the fastest growth in the Targeted Protein
Degradation market size report. Countries like China, Japan, and India are
significantly investing in biotechnology and pharmaceutical research, which is
propelling the growth of the TPD market. The growing incidence of diseases such
as cancer and neurodegenerative disorders in APAC countries creates a large
market for protein degradation therapies. APAC is increasingly moving towards
precision medicine, and TPD is expected to play a key role in providing
targeted therapies.
Middle East & Africa Market Statistics
Although the MEA
region has traditionally lagged in biotech development, recent healthcare
reforms are promoting greater adoption of innovative therapies. Cancer
treatment remains a significant focus in MEA, and TPD may find a growing market
for oncology-based therapies.
Latin America Market Statistics
As healthcare
systems in countries like Brazil and Mexico improve, there is growing demand
for innovative therapies, including targeted protein degraders. The prevalence
of cancer and infectious diseases in the region is likely to fuel the demand
for advanced treatments such as TPD therapies.
Key Market Players
The competitive landscape of the Global Targeted Protein Degradation (TPD) Market report is highly dynamic, with both established pharmaceutical companies and innovative biotech startups vying for leadership in this promising therapeutic area. The competition is primarily driven by technological advancements, strategic partnerships, and innovative product pipelines. Major companies dominating in the global Targeted Protein Degradation market report include Arvinas Inc., Bristol-Myers Squibb, GlaxoSmithKline (GSK), Kymera Therapeutics, and C4 Therapeutics, which have a significant market share.
The Global Targeted
Protein Degradation Market is dominated
by a few large companies, such as
·
Arvinas, Inc.
·
GlaxoSmithKline (GSK)
·
Amgen Inc.
·
Merck & Co., Inc.
·
Pfizer Inc.
·
Bayer AG
·
AbbVie Inc.
·
Novartis AG
·
Sanofi
·
Roche
·
Johnson & Johnson
·
Kymera Therapeutics
·
Nurix Therapeutics
·
C4 Therapeutics
·
Foghorn Therapeutics
·
BioAge Labs, Inc.
·
Others
1.
Global
Targeted Protein Degradation Market Introduction and Market Overview
1.1. Objectives of the Study
1.2. Global Targeted Protein
Degradation Market Scope and Market Estimation
1.2.1. Global Targeted Protein
Degradation Overall Market Size (US$ Bn), Market CAGR (%), Market forecast (2025
- 2035)
1.2.2. Global Targeted Protein
Degradation Market Revenue Share (%) and Growth Rate (Y-o-Y) from 2021 - 2035
1.3. Market Segmentation
1.3.1. Technology of Global Targeted
Protein Degradation Market
1.3.2. Application of Global Targeted
Protein Degradation Market
1.3.3. End-use of Global Targeted
Protein Degradation Market
1.3.4. Region of Global Targeted
Protein Degradation Market
2.
Executive Summary
2.1. Demand Side Trends
2.2. Key Market Trends
2.3. Market Demand (US$ Bn) Analysis
2021 – 2024 and Forecast, 2025 – 2035
2.4. Demand and Opportunity
Assessment
2.5. Demand Supply Scenario
2.6. Market Dynamics
2.6.1. Drivers
2.6.2. Limitations
2.6.3. Opportunities
2.6.4. Impact Analysis of Drivers and
Restraints
2.7. Pricing Trends Analysis
2.8. Overview of Technology Developments
2.9. Porter’s Five Forces Analysis
2.9.1. Bargaining Power of Suppliers
2.9.2. Bargaining Power of Buyers
2.9.3. Threat of Substitutes
2.9.4. Threat of New Entrants
2.9.5. Competitive Rivalry
2.10. PEST Analysis
2.10.1. Political Factors
2.10.2. Economic Factors
2.10.3. Social Factors
2.10.4. Technology Factors
2.11. Value Chain / Ecosystem Analysis
2.12. Key Regulation
3.
Global Targeted Protein
Degradation Market Estimates &
Historical Trend Analysis (2021 - 2024)
4.
Global Targeted Protein
Degradation Market Estimates &
Forecast Trend Analysis, by Technology
4.1. Global Targeted Protein
Degradation Market Revenue (US$ Bn) Estimates and Forecasts, by Technology, 2021
- 2035
4.1.1. PROTAC
4.1.2. Molecular Glues
4.1.3. LYTACs
4.1.4. Others
5.
Global Targeted Protein
Degradation Market Estimates &
Forecast Trend Analysis, by Application
5.1. Global Targeted Protein
Degradation Market Revenue (US$ Bn) Estimates and Forecasts, by Application, 2021
- 2035
5.1.1.Drug
Discovery
5.1.2.Therapy
Development
5.1.2.1.
Cancer
5.1.2.2.
Neurology
5.1.2.3.
Infectious Diseases
5.1.2.4.
Cardiovascular Diseases
5.1.2.5.
Others
6.
Global Targeted Protein
Degradation Market Estimates &
Forecast Trend Analysis, by End-use
6.1. Global Targeted Protein
Degradation Market Revenue (US$ Bn) Estimates and Forecasts, by End-use, 2021 -
2035
6.1.1.Pharmaceutical
& Biotechnology Companies
6.1.2.Academic
& Research Institutes
6.1.3.Hospital
& Clinical Laboratories
6.1.4.Others
7.
Global Targeted Protein
Degradation Market Estimates &
Forecast Trend Analysis, by Region
7.1. Global Targeted Protein
Degradation Market Revenue (US$ Bn) Estimates and Forecasts, by Region, 2021 -
2035
7.1.1. North America
7.1.2. Eastern Europe
7.1.3. Western Europe
7.1.4. Asia Pacific
7.1.5. Middle East & Africa
7.1.6. Latin America
8.
North
America Targeted Protein Degradation Market: Estimates & Forecast Trend Analysis
8.1.
North
America Targeted Protein Degradation Market Assessments & Key Findings
8.1.1. North America Targeted Protein
Degradation Market Introduction
8.1.2. North America Targeted Protein
Degradation Market Size Estimates and Forecast (US$ Billion) (2021 - 2035)
8.1.2.1. By Technology
8.1.2.2. By Application
8.1.2.3. By End-use
8.1.2.4. By Country
8.1.2.4.1. The U.S.
8.1.2.4.2. Canada
8.1.2.4.3. Mexico
9.
Western
Europe Targeted Protein Degradation Market: Estimates & Forecast Trend Analysis
9.1. Western Europe Targeted Protein
Degradation Market Assessments & Key Findings
9.1.1. Western Europe Targeted Protein Degradation
Market Introduction
9.1.2. Western Europe Targeted Protein
Degradation Market Size Estimates and Forecast (US$ Billion) (2021 - 2035)
9.1.2.1. By Technology
9.1.2.2. By Application
9.1.2.3. By End-use
9.1.2.4.
By
Country
9.1.2.4.1.
Germany
9.1.2.4.2.
Italy
9.1.2.4.3.
U.K.
9.1.2.4.4.
France
9.1.2.4.5.
Spain
9.1.2.4.6.
Benelux
9.1.2.4.7.
Nordics
9.1.2.4.8. Rest
of W. Europe
10. Eastern Europe Targeted
Protein Degradation Market: Estimates
& Forecast Trend Analysis
10.1. Eastern Europe Targeted Protein
Degradation Market Assessments & Key Findings
10.1.1. Eastern Europe Targeted Protein
Degradation Market Introduction
10.1.2. Eastern Europe Targeted Protein
Degradation Market Size Estimates and Forecast (US$ Billion) (2021 - 2035)
10.1.2.1. By Technology
10.1.2.2. By Application
10.1.2.3. By End-use
10.1.2.4. By Country
10.1.2.4.1.
Russia
10.1.2.4.2.
Hungary
10.1.2.4.3.
Poland
10.1.2.4.4.
Balkan & Baltics
10.1.2.4.5. Rest of E. Europe
11. Asia Pacific Targeted
Protein Degradation Market: Estimates
& Forecast Trend Analysis
11.1. Asia Pacific Market Assessments
& Key Findings
11.1.1. Asia Pacific Targeted Protein
Degradation Market Introduction
11.1.2. Asia Pacific Targeted Protein
Degradation Market Size Estimates and Forecast (US$ Billion) (2021 - 2035)
11.1.2.1. By Technology
11.1.2.2. By Application
11.1.2.3. By End-use
11.1.2.4. By Country
11.1.2.4.1. China
11.1.2.4.2. Japan
11.1.2.4.3. India
11.1.2.4.4. Australia & New Zealand
11.1.2.4.5. South Korea
11.1.2.4.6. ASEAN
11.1.2.4.7. Rest of Asia Pacific
12. Middle East & Africa Targeted
Protein Degradation Market: Estimates
& Forecast Trend Analysis
12.1. Middle East & Africa Market
Assessments & Key Findings
12.1.1. Middle
East & Africa Targeted
Protein Degradation Market Introduction
12.1.2. Middle
East & Africa Targeted
Protein Degradation Market Size Estimates and Forecast (US$ Billion) (2021 -
2035)
12.1.2.1. By Technology
12.1.2.2. By Application
12.1.2.3. By End-use
12.1.2.4. By Country
12.1.2.4.1. UAE
12.1.2.4.2. Saudi
Arabia
12.1.2.4.3. Turkey
12.1.2.4.4. South
Africa
12.1.2.4.5. Rest of
MEA
13. Latin America
Targeted Protein Degradation Market:
Estimates & Forecast Trend Analysis
13.1. Latin America Market Assessments
& Key Findings
13.1.1. Latin America Targeted Protein
Degradation Market Introduction
13.1.2. Latin America Targeted Protein
Degradation Market Size Estimates and Forecast (US$ Billion) (2021 - 2035)
13.1.2.1. By Technology
13.1.2.2. By Application
13.1.2.3. By End-use
13.1.2.4. By Country
13.1.2.4.1. Brazil
13.1.2.4.2. Argentina
13.1.2.4.3. Colombia
13.1.2.4.4. Rest of
LATAM
14. Country Wise Market:
Introduction
15. Competition Landscape
15.1. Global Targeted Protein
Degradation Market Product Mapping
15.2. Global Targeted Protein
Degradation Market Concentration Analysis, by Leading Players / Innovators /
Emerging Players / New Entrants
15.3. Global Targeted Protein
Degradation Market Tier Structure Analysis
15.4. Global Targeted Protein
Degradation Market Concentration & Company Market Shares (%) Analysis, 2023
16. Company Profiles
16.1. Arvinas, Inc.
16.1.1. Company Overview & Key Stats
16.1.2. Financial Performance & KPIs
16.1.3. Product Portfolio
16.1.4. SWOT Analysis
16.1.5. Business Strategy & Recent
Developments
* Similar details would be provided
for all the players mentioned below
16.2. GlaxoSmithKline
(GSK)
16.3. Amgen Inc.
16.4. Merck & Co.,
Inc.
16.5. Pfizer Inc.
16.6. Bayer AG
16.7. AbbVie Inc.
16.8. Novartis AG
16.9. Sanofi
16.10. Roche
16.11. Johnson &
Johnson
16.12. Kymera Therapeutics
16.13. Nurix Therapeutics
16.14. C4 Therapeutics
16.15. Foghorn
Therapeutics
16.16. BioAge Labs, Inc.
16.17. Others
17. Research
Methodology
17.1. External Transportations /
Databases
17.2. Internal Proprietary Database
17.3. Primary Research
17.4. Secondary Research
17.5. Assumptions
17.6. Limitations
17.7. Report FAQs
18. Research
Findings & Conclusion
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Frequently Asked Questions
What is the market size of Targeted Protein Degradation Market in 2025?
Targeted Protein Degradation Market was valued at USD 546.63 Million in 2025.
What is the growth rate for the Targeted Protein Degradation Market?
Targeted Protein Degradation Market size will increase at approximate CAGR of 21.2% during the forecasted period.
Which are the top companies operating within the market?
Major companies operating within the market are Arvinas, Inc., GlaxoSmithKline (GSK), Amgen Inc., Merck & Co., Inc., Pfizer Inc., Bayer AG, AbbVie Inc., Novartis AG, Sanofi, Roche, Johnson & Johnson, Kymera Therapeutics, Nurix Therapeutics and others.
Which region dominates the Targeted Protein Degradation Market?
North America dominates the market with an active share of 44%.
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